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This Knowledge Base article explains how to use the Datagrid to create a Section 508 compliant page. It does involve installing an ASP.NET Hotfix Rollup. From the article:
The Section 508 hotfix introduces new properties to make the DataGrid control accessible. These properties are UseAccessibleHeader, Caption, and CaptionAlign. By default, the value of UseAccessibleHeader is false. When UseAccessibleHeader is set to true, it renders DataGrid table headers in <TH> tags with a scope="col" attribute.
Please note that installing the hotfix does not make your site compliant by itself. There's much more to it. For more information see:
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